Propionyl chloride

It is the acyl chloride derivative of propionic acid.

It undergoes the characteristic reactions of acyl chlorides.

In derived chiral amides and esters, the methylene protons are diastereotopic.

[2] There have been efforts[3] to schedule Propionyl chloride as a DEA List 1 Chemical as it can be used to synthesize fentanyl.

Propionyl chloride is industrially produced by chlorination of propionic acid with phosgene:[4]