Prorenone (developmental code name SC-23133) is a steroidal antimineralocorticoid of the spirolactone group related to spironolactone that was never marketed.

[1] Prorenoate potassium is about 8 times more potent than spironolactone as an antimineralocorticoid in animals, and it may act as a prodrug to prorenone.

[2][3] The antiandrogenic potency of prorenone in vivo in animals is close to that of spironolactone.

[3] Similarly to spironolactone, prorenone is also a potent inhibitor of aldosterone biosynthesis.

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