The exact reason behind the reduced amount of successful pregnancies of primates during the study is unclear due a number of possibilities that may affect such result.
The synthesis of prostaglandins can be blocked by anti-inflammatory drugs such as ibuprofen.
Nonsteroidal anti-inflammatory drugs (NSAIDs) block the synthesis of cyclooxygenases (COX) which in turn produce prostaglandins.
Prostaglandin E2 is produced by PGE synthase via the activation of EP1-4 receptors.
Prostaglandin E2 is associated with the development of vascular diseases that lead to inflammation in the body.