[2][3] There are several different forms: Pseudin-2 is the most abundant version of the pseudins found on the skin of the paradoxical frog.
[8][9] Pseudin-2 was shown to have potent antibacterial activity, but a lower cytotoxicity.
[8] The cytotoxicity of a peptide can be measured by its effect on human erythrocytes.
[8] It is hypothesized that Pseudin-2 binding to the cell membrane of the bacteria results in a conformational change in which the peptide forms an α-helical shape, which allows it to perform cell lysis by inserting itself in the hydrophobic portion of the membrane.
[10] By increasing the cationicity and amphipathic nature of the molecule, it is possible to create analogues of Pseudin-2 that are even more selective towards bacteria.