Pyriprole, sold under the brand name Prac-tic, is a veterinary medication used for dogs against external parasites such as fleas and ticks.

[citation needed] Pyriprole applied as a spot-on is highly effective against fleas and several ticks species.

[citation needed] Efficacy against fleas is comparable to that of other modern insecticidal active ingredients such as fipronil, imidacloprid or spinosad.

It inhibits γ-aminobutyric acid (GABA)-gated chloride channels (GABAA receptors) resulting in uncontrolled hyperactivity of the central nervous system of fleas and ticks.

Following topical administration pyriprole is rapidly distributed in the hair coat of dogs within one day after application.