GRIT/Arhgap32) is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase activity.

PX-RICS is known to be involved in transport of certain synaptic proteins which lack ER export signals, from the endoplasmic reticulum, to the Golgi apparatus.

PX-RICS was found to be a necessary component for the export of this complex to the Golgi and then onwards to the cellular membrane.

PX-RICS is then thought to bind a heterodimer of the 14-3-3 proteins encoded by YWHAZ and YWHAQ genes.

[10] It has also now been shown that membrane transport of FGFR4, a N-Cadherin binding protein, is affected by PX-RICS knockdown.