The show's supporting cast was originally made up of Margera's fellow CKY crew members Brandon DiCamillo and Brandon Novak, who appeared on most episodes of the show's early years, with frequent guest appearances from Ryan Dunn, Rake Yohn and Chris Raab, as well as Bam's parents April Margera and Phil Margera, uncle Don Vito, and occasional appearances from the Jackass crew.
DiCamillo would also spend entire shows impersonating Rake for episodes where he was not present and the crew would often infuriate Rake by giving out his phone number live on air leading to hundreds of messages being left on his voicemail.
The show would often feature lengthy discussions about Novak's most recent sexual conquests and Bam would also take phone calls from listeners calling up to insult the show or the crew in order to mock them on air.
[1] For one episode in 2009, Bam spent the entire hour talking with Ginsburg about his recent stint in rehab for alcohol abuse.
On episode #143, Brandon Novak was kicked out of Bam's studio and sent home to Baltimore, Maryland, after they found drugs on him.