It starts from the end of Bamrung Mueang Road where it intersects Krung Kasem Road at the border between the districts of Pom Prap Sattru Phai and Pathum Wan.
From this point, it crosses Kasat Suek Bridge, also known as Yotse Bridge, which runs above Khlong Phadung Krung Kasem and the railway running from nearby Hua Lamphong railway station.
Other landmarks on the road include the Jim Thompson House, the Bangkok Art and Culture Centre, the Scala Cinema, and the Buddhist temple Wat Pathum Wanaram.
Late, King Vajiravudh renamed the road "Rama I" to commemorate the King Phutthayotfa Chulalok, also known as Rama I, who was the founder of the Rattanakosin Kingdom (presently Thailand) and the first monarch of the reigning Chakri dynasty.
The renaming alludes to a popular belief that Rama I, who at that time was serving as a general of King Taksin, had used the road to enter the inner city after returning from a war.