[11] On postnatal day 15, motor coordination deficits were evident on horizontal bar and inclined or vertical grid tests in association with a weaker grip strength.
Further differences were detected on postnatal day 22 and evaluation at the adult age revealed impairments indicative of permanent motor alterations.
As adults, Dab1(scm) mutants showed motor coordination impairments on stationary beam, coat-hanger, and rotorod tests but were more active in the open-field.
In mutants versus controls, changes in regional brain metabolism as measured by cytochrome oxidase (COX) activity occurred mainly in structures intimately connected with the cerebellum.
[13] Dab1-scm mutants are also characterized by reduced spontaneous alternation rates and deficits in visuomotor control while swimming towards a visible platform.