It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation.

[5] The Retinoic acid receptor beta aberrant promoter DNA hypermethylation has been observed associated with cancer onset/progression.

Indeed, this improper epigenetic phenomenon has been observed in women affected by Vulvar Squamous cell carcinoma arose from vulver lichen sclerosus.

[8] Methylation of the Retinoic acid receptor beta promoter may be a marker of cancer risk in patients affected by this disease.

[9] This article incorporates text from the United States National Library of Medicine, which is in the public domain.