These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription.

The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcription factors.

On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation.

[7] Click on genes, proteins and metabolites below to link to respective articles.

[§ 1] Retinoid X receptor alpha has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.