Going westward, it traverses many eastern Pennsylvania neighborhoods in Montgomery County including Conshohocken and beyond, connecting with Germantown Pike near Collegeville and continuing to Pottstown.

The intersection of 13th Street and Ridge Avenue is notable for being the location of Benjamin Franklin's kite experiment which led to the proof that lightning is electricity.

Portions of Ridge Pike carried U.S. Route 422 (US 422) before US 422 was moved to a freeway alignment between west of Pottstown and King of Prussia.

US 422 splits from Benjamin Franklin Highway onto the Pottstown Bypass freeway at an eastbound exit and westbound entrance east of the community of Douglassville in Amity Township in Berks County.

West High Street runs south-southeast through a mix of homes and businesses in the community of Stowe, turning to the northeast.

The road enters the borough of Pottstown and runs between residential and commercial development to the north and Norfolk Southern's Harrisburg Line parallel to the south, curving to the east-southeast.

East High Street heads north of the Montgomery County Community College West Campus and runs east through the commercial downtown of Pottstown as a three-lane road with a center left-turn lane, passing north of the Charles W. Dickinson Transportation Center serving PART buses before coming to an intersection with Hanover Street.

The road continues through the downtown area before running past a mix of homes and businesses in the eastern part of Pottstown.

From here, Ridge Pike continues east as a four-lane undivided road through commercial areas, narrowing to two lanes as it passes to the north of Heritage Field Airport.

The road gains a center left-turn lane as it heads through a mix of homes and businesses with some fields, curving to the southeast.

Ridge Pike gains a center left-turn lane as it continues southeast through residential and commercial development and some farmland and woodland.

[3][5] The road enters the borough of Trappe and narrows to two lanes as it passes homes and some businesses, coming to an intersection with PA 113.

The road curves to the south-southeast and passes through the commercial downtown of Collegeville before it crosses the Perkiomen Trail and comes to an intersection with PA 29.

At this point, West Main Street passes businesses and heads east-southeast into the commercial downtown of Norristown as a two-lane road.

The road loses the center turn lane and passes over the Pennsylvania Turnpike (I-276) and Norfolk Southern's Dale Secondary railroad line, running through commercial areas and coming to a bridge over Norfolk Southern's Morrisville Connecting Track railroad line.

Ridge Pike heads east past several businesses, curving southeast and becoming a divided highway at the Alan Wood Road intersection that has a westbound jughandle.

Ridge Avenue heads south-southeast as a five-lane road with a center left-turn lane through a mix of residential and commercial areas in the Andorra neighborhood.

At this point, Ridge Avenue becomes a two-lane undivided road that heads south-southeast into the Roxborough neighborhood, passing a mix of homes and businesses.

Ridge Avenue continues southeast past several businesses and some homes, passing northeast of Roxborough High School.

The road passes under the Twin Bridges which carry US 1 (Roosevelt Expressway) across the Schuylkill River, at which point it comes to ramps that provide access to northbound US 1 and from southbound US 1, before crossing under CSX's Trenton Subdivision railroad line.

US 13 splits to the south onto 33rd Street north of SEPTA's 33rd and Dauphin Bus Loop and Ridge Avenue continues southeast into the Strawberry Mansion neighborhood, passing through urban areas of homes.

Ridge Avenue continues through urban development and passes over Amtrak's Northeast Corridor railroad line.