The River to River Trail is a 160 mile (256 km)-long hiking trail that serves Shawnee National Forest in far southern Illinois.

Its eastern terminus has historically been Battery Rock, overlooking the Ohio River but now generally Elizabethtown, Illinois is used as the eastern terminus.

The western terminus is in Grand Tower, Illinois, at the Mississippi River.

Sections of the River to River Trail form part of the Southern Section of the American Discovery Trail.

[1] A significant spur trail serves Elizabethtown, Illinois.