In 2004, Williams set Lions rookie records with 54 receptions for 817 yards and eight touchdowns in 12 games; he suffered an ankle injury midway through the season that limited his effectiveness.

[9] The following season, the team spent their first-round draft pick (10th overall) on yet another receiver, this time USC star Mike Williams (no relation).

Williams was the 2007 recipient of the Detroit Lions/Detroit Sports Broadcasters Association/Pro Football Writers Association's Media-Friendly "Good Guy" Award.

The Good Guy Award is given yearly to the Detroit Lions player who shows consideration to, and cooperation with the media at all times during the course of the season.

[18] In 2009, with the release of Owens, Williams was expected to take over as the team's leading wide receiver,[19] but against the Kansas City Chiefs, as a replacement for the injured Williams, Miles Austin had a breakout game with 10 receptions for 250 yards (a Cowboys record for receiving yards in a single-game, breaking Bob Hayes' 246-yard effort in 1966) and 2 touchdowns.

[20] In 2010, the Cowboys drafted future Pro Bowler Dez Bryant in the first round, but Williams retained his starting role alongside Austin.

[21] His best game with the Cowboys was against in-state rival Houston Texans, in which he recorded 117 receiving yards and two touchdowns on five catches while only being targeted six times.

Williams played a small role in the 2004 sports film Friday Night Lights (his older brother, Lloyd Hill was on the team the movie was based on).

Williams played the role of an assistant coach for Midland Lee High School, which is one of Permian's biggest rivals.

His older brother Lloyd Hill, was the Texas Tech University all-time leading receiver and led the NCAA in receptions in 1992.