[1] The São Lourenço river basin lies in the Mato Grosso state of Brazil.

[3] It flows west into the Encontro das Águas State Park, where it is joined by the Cuiabá River.

The park is bounded to the south by the Piquiri River, which defines the border with the state of Mato Grosso do Sul.

The Piquiri flows west to join the São Lourenço at the southwest boundary of the park.

[3] It forms part of the southern boundary of the Pantanal Matogrossense National Park just before joining the Paraguay.