Domagnano currently plays in Girone B of Campionato Sammarinese di Calcio.

Previously known as SP Domagnano, the side has been one of the most successful teams in the Campionato Sammarinese.

In the 2004–05 season, Domagnano won the championship with a play-off win over S.S. Murata.

As the Sammarinese champions, Domagnano entered the UEFA Cup but was defeated easily in the first qualifying round.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.