The species least related to humans with a SKIDA1 ortholog is the lancelet Branchiostoma belcheri.

[12] It shares DUF4584 with Elongin BC Polycomb Repressive Complex 2 associated Protein (EPOP).

[15] Other mammalian species also have multiple isoforms of SKIDA1, including carnivorans, rodents, and primates.

[17][18] The poly-glutamic acid region shows more conservation, and is found abbreviated in species as distantly related from humans as the tire track eel.

The C-terminus of EPOP binds to the SUZ12 subunit of Polycomb Repressive Complex 2 (PRC2), suggesting that of SKIDA1 may as well.

Two align with the second half of the mRNA transcript, suggesting they are not used or only produce an incomplete polypeptide.

[8] SKIDA1 is expressed at high levels in the brain, thyroid, and testes.

It's expressed at medium to low levels in adipose tissue, lymph nodes, and skeletal muscle.

[29][30][31][32] In mice, it's noted to have medium-to-high expression in the olfactory bulb, retina, and salivary gland.

[32] SKIDA1 in the African clawed frog is expressed faintly in the marginal zone of gastrulae.

By the end of tailbud, neural expression has faded except in the olfactory organ.

Other significant differences include effected hearing, an enlarged thymus, and increased pre-weaning mortality.

[37] Its expression is altered by various cancer-treatment compounds: human alpha-lactalbumin made lethal to tumor cells; oleate salts; metformin; and aspirin.

[38][39] Altered methylation of SKIDA1 is associated with human pancreatic cancer, rheumatoid arthritis, and lupus erythematosus.