As other receptors from this family, SLAMF1 is expressed in different types of hematopoietic cells and it plays a role in the regulation of the immune system.

[7][8] The interaction of SLAMF1 promoter and enhancers with the Early B-cell factor 1 (EBF1) is required for the expression of SLAMF1 gene in B cells.

STAT6, IRF4, and NF-kB factors involved in the transfer of the signals from the B-cell receptor, its co-receptors and IL-4R, also play important role in the regulation of SLAMF1 expression.

[7][10] Binding of SAP to ITSMs leads to the activation of the kinase Fyn that phosphorylates tyrosines of SLAMF1 and recruits downstream signaling proteins.

Because of the high affinity of SAP to tyrosine phosphorylated ITSMs, it outcompetes the phosphatases which are the mediators of the inhibitory signal.

This interaction mediates a secondary signal crucial for NKT cell differentiation and expansion in the thymus.

It is internalized after the recognition of Gram-negative bacteria, and it plays a role in the regulation of phagosome maturation, ROS and NO production.

[7] This genus of viruses includes agents causing measles in humans, rinderpest in cattle and distemper in dogs and cats.

[7] nCD150 isoform was found in tumors of the central nervous system, such as glioblastoma, anaplastic and diffuse astrocytoma and ependymoma.