[8] It is evolutionarily conserved across eukaryotes and participates in several cellular and disease pathways, especially in neuronal and muscular development.

The RRMs play a role in RNA binding, while the AcD engages in protein-protein interactions (PPIs).

[12] The AcD is linked to RRM1 by a unique α-β-β unit, creating an “extended RRM fold” mediated primarily by hydrophobic interactions.

[12] The RGG box is an unstructured region containing numerous Arg-Gly-Gly repeats with fairly regular spacing.

[6] Isoform 1 is also implicated with other RBPs in the cytoplasmic de-adenylation and translational and decay interplay of c-Fos mRNA mediated by the major coding-region determinant of instability (mCRD) domain.