Safflorite is a rare cobalt iron arsenide mineral with the chemical formula (Co,Fe)As2.

Pure safflorite is CoAs2, but iron is virtually always present.

Safflorite is a member of the three-way substitution series of arsenides known as the loellingite group.

Safflorite along with the other minerals crystallize in the orthorhombic system forming opaque gray to white massive to radiating forms, Clinosafflorite has a monoclinic symmetry.

Safflorite occurs with other arsenide minerals as an accessory in silver mining districts.