[1] The first religious building on the site of the present church was a Roman monument, perhaps a temple of Attis, whose worship was probably the cause of the Christian persecution in Lyon from 177.

[5] It suffered the damage caused by several bands of Huguenot, which plundered the bishops of Lyon's tombs, then those of the French Revolution.

In the late 18th century, the project to transform the church into a gallery was abandoned after a petition signed by 100 notables.

In the beginning in 1968, renovations undertaken by the management of the monument historique and the city of Lyon began, and they ended in 1998.

In the 19th century, the parish hosted famous spiritual people such as Frederic Ozanam, founder of the Saint-Vincent de Paul conferences, and Pauline-Marie Jaricot, foundress of the Propagation of the Faith.