Saint Nicholas in Glory is an altarpiece painting by Italian Renaissance artist Lorenzo Lotto, executed in 1527-1529 and located in the church of Santa Maria dei Carmini, Venice.

An inscription at the altar's base reports that the canvas was commissioned in 1527 by the guardiano (curator of the church) Giovanni Battista Donati and his vicar Giorgio de' Mundis.

According to a pattern inspired by Albrecht Dürer's prints, Lotto placed St. Nicholas in the upper center, with a luminous halo crowning his face.

The saint is looking upwards, suggesting that he is ascending, and is surrounded by three angels who keep his mantle open and hold his traditional symbols: the mitre, the episcopal crozier and three golden balls, in memory of the three maidens saved by Nicholas according to the legend.

The lower part is occupied by a dark landscape, featuring, amongst other details, a sea harbor and a port struck by a storm.