San Buenaventura de Potano was a Spanish mission near Orange Lake in southern Alachua County or northern Marion County, Florida, located on the site where the town of Potano had been located when it was visited by Hernando de Soto in 1539.
In 1564, and again in 1565, the Utina chiefdom on the St. Johns River and the French (from Fort Caroline) raided the town of Potano.
[6] A town named Apalo is shown on the Jacques le Moyne map, located to the northeast of Potano.
In 1608 Mission San Buenaventura de Potano was established in the site of the old town by Fray Francisco Pareja.
The mission, under the name of San Buenaventura, disappeared from Spanish records after 1613, probably because the population was reduced and scattered by epidemics.