Sancti Spíritus (Spanish pronunciation: [ˈsaŋktjesˈpiɾitus]) is one of the provinces of Cuba.

The northern coast contains significant wetlands and protected areas such as the Bay of Buena Vista and the Caguanes National Park.

The largest man-made reservoir in Cuba, the Embalse Zaza, is in Sancti Spíritus province.

During the 17th century, both Dutch and British pirates attempted to take control of what is today Sancti Spíritus province, but with little success, as the Spanish garrison held them off.

Tourism is a big earner for the province, with most of the tourism centered on the old city of Trinidad, a World Heritage-listed city which has dozens of colonial buildings (and almost no 20th-century architecture), dating back to the Spanish conquest in the 16th century.