[9] In spring 2020, Cooper began publishing a series of videos on TikTok in which she lip-synced comments by Donald Trump on the topic of potential cures for the 2019 coronavirus.

[16] Her first viral satire, titled "How to Medical", features her lip-syncing a minute of audio from the April 23 press briefing during which Trump suggested[17][18][19] that shining light into the body and injecting disinfectant would be an effective method for treating the coronavirus.

[22] Cooper also redistributed her "How to Bible" TikTok video using her Instagram, Twitter, and YouTube accounts, achieving a combined total of 16 million views by the end of 2020.

[23] The Boston Globe remarked that Cooper's videos are also noted as being examples of extremely economical political satire since they are structured around an unedited voice clip of a politician speaking.

[24] This extremely minimalistic comedic approach, which includes neither a script nor an audience, was described as an innovative response to the limitations that comedians faced during COVID-19 lockdowns.

[23] Cooper analyzed the videos by commenting that "I had taken away the suit and the podium and the people behind him smiling and nodding and calling him "sir," and all that was left were his empty words, which, in reality, were not the best.

[29] In the wake of the popularity of her TikTok videos, Cooper was invited to appear on The Last Word with Lawrence O'Donnell and The Ellen DeGeneres Show.

The show is structured around spoofs of news segments, interviews, and commercials, and it incorporates a series of sketches featuring appearances from celebrities including Jon Hamm, Whoopi Goldberg, Helen Mirren, Ben Stiller, and Marisa Tomei.

[36] Cooper's character is a news anchor who struggles to retain her sanity and positive attitude despite the dramatic upheaval that she is reporting on, which is a commentary on the experience of observing the political, economic, and pandemic-related disruptions throughout the world in 2020 (as is the sarcasm of the title, Everything's Fine).

The Guardian rated the show 4 out of 5 stars, calling it "a funny and striking document of what living feels like in this fraught and febrile year.

[39] It was announced in August 2020 that Cooper and Cindy Chupack would be producing a comedy show for CBS based on How to Be Successful Without Hurting Men's Feelings.