Carlton Drake was experimenting with symbiotes in the hopes of creating so-called 'super-cops' to watch over the imagined fallout shelter utopia, and Donna was picked from the security force made up of police, soldiers and mercenaries.

The age-accelerating machine appeared to make the symbiotes age to dust before the Life Foundation blew up the base.

When Scarlet Spider refused, Scream experienced a psychotic break and began a rampage in Times Square.

Humiliated when Venom ripped pieces of her symbiote off her and narrowly saved by the Scarlet Spider, Scream disappeared again.

After her companions began dying mysteriously, Donna tracked Xenophage, a huge alien that devours both symbiotes and their hosts' brains.

The ship transported her and others (including Venom and Wolverine) into another dimension where Scream gets nearly killed once again by the villainous mutants Dirtnap and Chimera.

[7] Scream appeared in two panels of the Marvel Super Hero Island Adventures comic giveaway from 1999, as she is shown to be a member of the Sinister Syndicate.

Donna's family name Diego is first established (many years after her first appearance as a character in the Marvel Universe) via files where she is quoted as being an "enemy combatant" to the Initiative's forces.

Patricia Robertson (who had previously hosted a clone of Venom) later ambushes but the Scream symbiote decides to bond to her, leaving Donna's bones behind.

Lunging at her, Carnage impales Scream and snarls that he's the voice inside her head telling her to stay and die.

Scream snares with tendril hair and slams Carnage into the dangling meat, Andi noting that even with a symbiote she's not powerful enough to fight.

Smashing the door off its hinges, Carnage notes that Andi has escaped and grouses of having to wait for another rematch with her before turning to harvest the Mania and Scream codices from Patricia's corpse.

[14] The Scream symbiote appears in the Spider-Man series finale "Maximum Venom", voiced by Meg Donnelly.