The station forms part of the important rail link originally built as the South railway, between Vienna, Austria, and Trieste, Italy.

After World War I, and the annexation of Sežana to the Kingdom of Italy, the station was renamed Stazione di Sesana (its Italian language name).

Responsibility for operating the station passed to the Ferrovie dello Stato (State Railways of the Kingdom of Italy).

In 1947, following the end of World War II, the Socialist Federal Republic of Yugoslavia took control of Sežana.

Media related to Sežana train station at Wikimedia Commons This article is based upon a translation of the Italian language version as at November 2010.