The river flows northeast into the province of Ravenna and flows near Casola Valsenio, Riolo Terme, Castel Bolognese, Cotignola, Lugo, Bagnacavallo, Fusignano and Alfonsine before entering the Reno.

[1] The river has a tributary called the Sintria that flows into it east of Riolo Terme.

[citation needed] The area was the site of several hard-fought battles in the Spring of 1945, during the last phases of World War II in Europe.

The Allied crossing of the River Senio was one of the last hurdles that needed to be overcome in order to capture the great Po Valley basin and so complete the campaign in Italy.

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