Proteins of this family are predicted to be utilised in multiple morphogenic and developmental processes across animal phyla to regulate cells shape or intracellular architecture in an actin and myosin-dependent manner.
[2] In mice and humans, the Shrm family of proteins consists of: This protein family is based on the conservation of a specific arrangement of an N-terminal PDZ domain, a centrally positioned sequence motif termed ASD1 (Apx/Shrm Domain 1) and a C-terminal motif termed ASD2.
To date, the ASD1 and ASD2 elements have only been found in Shrm-related proteins and do not appear in combination with other conserved domains.
ASD1 is required for targeting actin, while ASD2 is capable of eliciting an actomyosin based constriction event.
Despite their diverse biological roles, Shroom family proteins share a common activity.