409017129ENSG00000113658ENSMUSG00000021540Q99717P97454NM_005903NM_001001419NM_001001420NM_001164041NM_001164042NM_008541NP_001001419NP_001001420NP_005894NP_001157513NP_001157514NP_032567Mothers against decapentaplegic homolog 5 also known as SMAD5 is a protein that in humans is encoded by the SMAD5 gene.

[5] SMAD5, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic", based on a tradition of such unusual naming within the gene research community.

The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein.

It may play a role in the pathway where TGFβ is an inhibitor of hematopoietic progenitor cells.

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