The highway connects rural areas of Anderson County with Starr.

SC 412 begins at an intersection with U.S. Route 29 (US 29) west-northwest of Starr, within unincorporated Anderson County community of Holland Store.

It crosses over Lucas Creek before it intersects SC 187.

A short distance after crossing Weems Creek, it passes Starr–Iva Middle School.

In Starr, it intersects the northern terminus of SC 181 (Smith–McGee Road) just before it meets its eastern terminus, an intersection with SC 81.