South Carolina Highway 2 (SC 2) is a state highway in the U.S. state of South Carolina that travels 3.9 miles (6.3 km) between two portions of U.S. Route 21/U.S.

SC 2 is a 3.9-mile (6.3 km), two-lane road just southwest of Columbia, serving as a business route for Cayce.

It then takes a turn to the north and runs parallel to the Congaree River to its west.

The original path went from the Georgia state line north of Mountain Rest heading east towards Greenville before turning southeast and ending in Charleston, spanning over 250 miles (400 km).

Additionally, only the Frink Street portion of the route is signed, and minimally at that.