South Carolina Highway 417 (SC 417) is a 21.699-mile (34.921 km) state highway in central Greenville and Spartanburg counties in the northwestern part of the U.S. state of South Carolina.

SC 417's western terminus is at junction with U.S. Route 276 (US 276) in Mauldin and near the junctions of Interstate 385 (I-385) and I-185.

Its overall course is in a northeasterly direction, and SC 417's eastern terminus is at a junction with SC 296 near Spartanburg.

From SC 417's western terminus to its split from SC 14, SC 417 is known as Main Street and Laurens Road.

When it splits from SC 146, SC 417 is known only as Highway 417, and it keeps that name until it reaches its eastern terminus.