South Carolina Highway 418 (SC 418) is a 24.740-mile (39.815 km), east–west state highway in upstate South Carolina.

It then proceeds in an east-northeast direction to Fountain Inn, crossing Interstate 385 (I-385) at exit 23 before entering the city.

After the interchange, the highway intersects SC 14 and takes a north-northeast route, following almost parallel to the Greenville-Laurens County border.

It then cuts across the northern corner of Laurens County heading through rural areas of the county without passing any incorporated towns or intersecting any other state highways.

It travels across the Enoree River to head east into Spartanburg County, and coming to its east terminus on the outskirts of Woodruff at the intersection with SC 101/SC 146.