South Carolina Highway 522 (SC 522) is a 29.620-mile (47.669 km) primary state highway in the U.S. state of South Carolina.

It serves to connect communities in central Lancaster County.

SC 522 is a two-lane rural highway, from Liberty Hill to the North Carolina state line, near Sapps Crossroads.

It is similar to a Farm-to-market road that it provides no real destination for travelers, but does provides access to farmland in central Lancaster County.

In 1951 or 1952, SC 522 was extended east to its current eastern terminus in Liberty Hill.