South Carolina Highway 541 (SC 541) is a 10.660-mile (17.156 km) state highway in the U.S. state of South Carolina.

The highway connects Olanta with Coward.

SC 541 begins at an intersection with SC 341 (East Hampton Street/Olanta Highway) just east of Olanta, within Florence County.

It travels to the east-northeast and crosses over Camp Branch before intersecting SC 403 (North Bethel Road).

When it enters Coward, it curves to the northeast and meets its eastern terminus, an intersection with U.S. Route 52 (US 52).