It is co-signed with Jones County Route X44 until the Monticello city limits.

US 151) is a business route of US 151 in Platteville, Wisconsin that is 3.6 miles (5.8 km) long.

US 151) is a business route of US 151 in Mineral Point, Wisconsin that is 3.7 miles (6.0 km) long.

Inside Mineral Point, the route becomes concurrent with Wisconsin Highway 39.

The route is also shared by US 18 Business, as well as parts of Wisconsin Highway 78 and Dane County Road ID.

The route is also shared by US 18 Business and Dane County Road MV.

US 18 Business/151 Business/CR MV begins at a pair of flyover interchanges with US 18/151 on Exit 76 west of Verona.

From there, the business routes run east-northeast as a four-lane divided highway until the intersection with Legion Street, where it becomes a local two-lane undivided road.

At the intersection with North and South Main Streets (Dane County Road M), West Verona Avenue becomes East Verona Avenue, making a brief reverse curve to the left before returning to its previous trajectory at School Street and becoming a four-lane divided highway east of there.

US BUS 18/151/CR MV ends east of Verona at Exit 81 on US 18/151, but only with an eastbound on-ramp and westbound off-ramp.

US 151) is a business route of US 151 in Sun Prairie, Wisconsin that is 2.9 miles (4.7 km) long.

US 151) is a business route of US 151 in Columbus, Wisconsin that is 3.8 miles (6.1 km) long.

US 151) is a business route of US 151 in Beaver Dam, Wisconsin that is 4.6 miles (7.4 km) long.

US 151) is a business route of US 151 in Waupun, Wisconsin that is 5.1 miles (8.2 km) long.