WIS 73 starts in Dane County at an interchange with Interstate 39 (I-39), I-90 and US Highway 51 (US 51) north of the city of Edgerton.

WIS 73 then heads north-northwest, crossing into Marquette County at Eagle Road, to Neshkoro.

WIS 73 continues west for four miles (6.4 km) to the Wisconsin River where it enters the city of Nekoosa.

WIS 73 heads west seven miles (11 km) to where it crosses into Clark County.

It crosses into Taylor County about five miles (8.0 km) north of WIS 29.

They are cosigned heading north before WIS 64 splits just east of Gilman.

WIS 73 continues north to Jump River before entering Rusk County.

It continues north for nine miles (14 km) to Ingram, where WIS 73 ends at US 8.