Spermatogenesis arrest

Spermatogenesis arrest is known as the interruption of germinal cells of specific cellular type, which elicits an altered spermatozoa formation.

However some cases may be consecutive to hormonal, thermic, or toxic factors and may be reversible either spontaneously or after a specific treatment.

FSH uses very specific G-coupled receptors that can be found only on Sertoli cells, this hormone is secreted by the pituitary gland, located in the brain.

FSH plays a role in the spermatogenic capacity of the adult male as it controls the proliferation of Sertoli cells during either the perinatal or pubertal period, or both.

It has been found through studies that spermatogenetic arrest tends to occur in the late spermatocyte/spermatid stage when the androgen receptor activation in Sertoli cells is interrupted or affected in some way.

A study done by Jungling and Bunge in 1976 had a small breakthrough in the field by orally distributing arginine, daily to a group of infertile men.