Spring Creek begins on the base of North White Deer Ridge in Washington Township, Lycoming County.

The creek then gradually turns southeast, receiving two more unnamed tributaries from the left and passing through a small pond.

Jesse Weeks inhabited a cabin on the northern side of the creek, approximately 4 miles (6.4 km) upstream of its mouth.

[7] Isaac Hains built the fifth mill in Washington Township, Lycoming County on Spring Creek.

[8] A concrete tee beam bridge carrying T-528 over Spring Creek was built in Gregg Township, Union County in 1919 and is 44.0 feet (13.4 m) long.

A prestessed box beam or girders bridge carrying Pennsylvania Route 44 over the creek was built in 2007 0.5 miles (0.80 km) west of Spring Garden and is 94.2 feet (28.7 m) long.

[9] A two-span concrete stringer/multi-beam or girder bridge carrying State Route 2003 over the creek was built in 1915 2 miles (3.2 km) northeast of Elimsport and is 42.0 feet (12.8 m) long.

A prestresed box beam or girders bridge carrying State Route 2001 across Spring Creek was constructed in 1959 and repaired in 2011.