In Serbian, the district is known as Sremski okrug (Сремски округ), in Croatian as Srijemski okrug, in Hungarian as Szerémségi Körzet, in Slovak as Sriemskí okres, in Rusyn as Srimski okruh (Сримски окрух), and in Romanian as Districtul Srem.

The District includes the municipalities of: In Late antiquity, between the 3rd and 5th centuries, the city of Sirmium (present-day Sremska Mitrovica) was a capital of the Roman province of Pannonia Secunda.

During the administration of the medieval Kingdom of Hungary (12th–16th century), the area was divided between Sirmiensis and Valkoensis counties.

Ethnic composition of the Srem district:[3] The monasteries on the Fruška Gora mountain are the greatest cultural treasures of this region.

Archeological Museum Carska Palata (Royal Palace) in Sremska Mitrovica is dedicated to the remains of the Roman town Sirmium, dating back to 1st century BC.

[5] A museum dedicated to the prominent Serbian artist Sava Šumanović is located in his hometown of Šid.

It consists of the Gallery with 417 works of art, donated by Sava's mother Persida Šumanovic, and the Memorial House, where the painter used to live with his family.