[1] The network was founded in 1872 when St. Luke's Hospital was chartered in South Bethlehem.

In 1875, the hospital was relocated to its current location in Fountain Hill, Pennsylvania.

Upon his death in 1878, local businessman Asa Packer entrusted $300,000 worth of shares in the Lehigh Valley Railroad to the hospital.

The health network celebrated its 150th anniversary in 2022 and established a new children's hospital the following year.

St. Luke's University Health Network is a member of the Council of Teaching Hospitals and Health Systems and offers 90 medical specialties, including: St. Luke's University Health Network comprises fourteen hospitals: The network's 300 outpatient sites provide various healthcare services, including: