[13] Abington Memorial Hospital, Aria Health, and Einstein Healthcare Network formed the alliance in July 2013.

The initiative was intended to encourage collaboration between the four health systems in order to provide the Philadelphia and its suburbs with more comprehensive care.

In April 2016, the board of managers of Noble Health Alliance announced its decision to dissolve the organization.

[14] In January 2016, Crozer-Keystone entered into a definitive agreement for the health system to be acquired by Prospect Medical Holdings, Inc.[15] On July 1, 2016, Prospect Medical Holdings, Inc. completed its acquisition of Crozer-Keystone Health System after receiving all necessary regulatory approval.

[17] The health system was placed under financial stress during the COVID-19 pandemic due to supply chain issues and rising costs, causing government spenders to account for 60% of the hospital's income.

[20] Crozer-Chester Medical Center (Crozer) is a 424-bed tertiary-care teaching hospital located on a 68-acre campus in Upland, Pennsylvania.

[22] Delaware County Memorial Hospital is a 225-bed facility in Drexel Hill, Pennsylvania, that offers a broad range of acute and specialized services.

Crozer Health suspended all hospital-based services at the complex on January 14, 2022, including the emergency room and inpatient care.