Penn Highlands experienced significant operating losses in 2023 and 2024, as did some other healthcare providers in Western Pennsylvania including Allegheny Health Network (AHN) and University of Pittsburgh Medical Center (UPMC).

Penn Highlands WRC Senior Services is based in Brookville and has origins in the late 1800s as the Woman's Relief Corps.

[10][11] Penn Highlands DuBois is located adjacent to the organization's headquarters and hosts the only level II trauma center in Central Northwestern Pennsylvania.

[16] In 2024, Penn Highlands and multiple PH hospitals agreed to pay $735,000 to the United States pursuant to a lawsuit.

A US attorney alleged that PH DuBois violated the Physician Self-Referral Law from 2009 to 2012, and a whistleblower complaint was filed in 2016.

In 2024, PH Elk both closed its maternity ward and submitted a letter of intent to become a level IV trauma center.

Penn Highlands referred Elk County patients to their DuBois location, while some groups consider the area to be a "maternity care desert.

[20] Penn Highlands State College was built from the ground up for the organization and opened in 2024 as a campus of PH Huntingdon.

[27] In 2020, Tyrone Hospital and a supervising radiologist were ordered to pay $10.83 million after a patient suffered brain damage after experiencing an allergic reaction during an imaging procedure.