Saint Paul College of Ilocos Sur, also referred to by its acronym SPCIS or SPC Ilocos Sur, is a private Catholic basic and higher education institution run by the Sisters of St. Paul of Chartres (SPC) in Bayubay, San Vicente, Ilocos Sur.

It is one of the 40 schools owned, managed, and operated by the Sisters of St. Paul of Chartres (SPC) in the Philippines.

The school was originally established in Vigan, Ilocos Sur, in 1905 by the Sisters of St. Paul of Chartres.

Secondary Education was introduced in 1912, a Junior Normal College was started in 1946, providing courses in the Liberal Arts, an Elementary course in Piano (1950), and a four-year Bachelor of Science in Elementary Education.

The school expanded to a new site in Barangay Bayubay, in the nearby municipality of San Vicente.