It continues south through Northcote until it reaches Merri Parade, where it narrows to a four-lane, single-carriageway road, sharing surface tram tracks.

Running south-west, it crosses Merri Creek through Fitzroy North until it ends upon reaching Brunswick Street.

Metropolitan Route 38 runs concurrent along St Georges Road from Merri Parade at Northcote to Holden Street at Fitzroy North from 1965.

In the early 1990s, the tram tracks from Merri Place to Miller Street were rebuilt in a dedicated reservation.

[13] Until the mid-2009 there was a large roundabout at the intersection of St Georges Road, Merri Parade and Charles Street which has been replaced with traffic lights.