In 1947, plans were made for a new Catholic Central High School in the West End of Steubenville (the present location).

On January 15 of that year, nine pastors and lay chairmen from each of their parishes met with Mussio in order to formulate plans for a drive to provide funds for the building of the new school.

A tract of land, the old Becker Highway property, was purchased; contracts were let and the present building was begun early in 1949.

In 2008, the Bishop Mussio Junior High, housing 7th and 8th grade students was added to the former religion wing.

CCHS competes in the Class AA division of the Ohio Valley Athletic Conference.