Streptolysin

[6] This toxin excreted by a Gram-positive bacteria Streptococcus pyogenes, under the classification of Thiol-activated cytolysin or CDCs.

Unlike other Cholesterol-dependent cytolysins, SLO contains a 60 Amino acid N-terminal domain that makes it easier to identify.

Human serum albumin has been demonstrated to neutralize the cytotoxic and hemolytic effects of SLO through its binding in a non-conventional site located in domain II, previously reported to interact also with C. difficile toxins.

[9] Streptolysin S (SLS; sagA), is a cytolytic virulence factor which is a membe of the thiazole/oxadole-modified microcin (TOMM) family.

SLS is responsible for Streptococcus pyogenes' β-hemolytic appearance when grown on blood agar plates.

[11] Streptolysin O (SLO) is integral to the development of assays designed to detect Anti-Streptolysin O (ASO) antibodies in clinical settings.