[2] Numerous secondary symptoms of vasculitis can occur, such as thrombosis, aneurysm formation, bleeding, occlusion of an artery, loss of weight, exhaustion, depression, fever, and widespread pain that worsens in the morning.

[2] Systemic vasculitides are categorized as small, medium, large, or variable based on the diameter of the vessel they primarily affect.

[6] The disease's symptoms can range from catastrophic neurological impairment to an asymptomatic condition brought on by impalpable pulses or bruits.

[7] Non-specific features include mild anemia, myalgia, arthralgia, weight loss, malaise, night sweats, and fever.

[10] Kawasaki disease is a type of systemic vasculitis of medium-sized vessels with an acute onset that primarily affects young children.

It manifests pathologically as an inflammatory response pattern in the kidneys, upper and lower respiratory tracts, and granulomatous inflammation, which includes necrosis.

[5] Hypocomplementemic urticarial vasculitis syndrome is a rare immune complex-mediated condition that has persistent acquired hypocomplementemia and urticaria.

Cryoglobulins type II and III, also known as mixed cryoglobulinemia, are composed of polyclonal immunoglobulin (Ig)G and either monoclonal IgM or both with rheumatoid factor activity.

The disease can present with a wide range of symptoms, from minor ones like fatigue, purpura, or arthralgia to more serious ones like glomerulonephritis and widespread vasculitis that can be fatal.

[18] Anti-glomerular basement membrane disease is an uncommon kind of small vessel vasculitis that affects the kidney and lung capillary beds.

[24] Giant cell arteritis (GCA) often exhibits a wide range of symptoms in its early stages, all of which are related to the localized consequences of systemic and vascular inflammation.

[26] A variety of clinical indicators, including common symptoms like fever, chills, weight loss, myalgia, and arthralgia, are typically present when PAN first manifests.

The term "modifications of the oral cavity" usually refers to conditions such as diffused erythema of the oropharyngeal mucosa, strawberry-like tongue without vesicles or pseudo-membrane formation, bleeding of the lips, redness, fissuring, and dryness.

[3] Malaise, arthralgia, sinusitis, and rhinitis are typically present at the beginning of Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis.

As a result, the conditions most frequently manifested as Raynaud's phenomenon, distal gangrene, ischemic ulcers, purpura, livedo reticularis, headache, retinal hemorrhages, and encephalopathy.

[30] Recurrent urticaria, with skin eruptions primarily affecting the trunk, face, and upper extremities, is the primary clinical manifestation of hypocomplementemic urticarial vasculitis.

Non-syphilitic interstitial keratitis (IK), uveitis, retinal vasculitis, conjunctivitis, scleritis, tinnitus, hearing loss, and vertigo are among the range of ocular manifestations.

[23] Patients with vasculitis frequently have increased erythrocyte sedimentation rate and elevated C-reactive protein levels; however, these symptoms are nonspecific and can arise in a variety of circumstances, most notably infection.

When vasculitis is not active, normal erythrocyte sedimentation rate or C-reactive protein level can occur and should not rule out the diagnosis.

When paired with congruent clinical features, an elevated erythrocyte sedimentation rate in giant cell arteritis patients can both support the diagnosis and aid in disease monitoring.

Serum bilirubin and liver enzyme levels (ó-glutamyltransferase, alkaline phosphatase, and aspartate and alanine transaminase) can give indications for liver-related vasculitis, like polyarteritis nodosa.

[23] Antineutrophil cytoplasmic antibodies (ANCAs) are a diverse collection of autoantibodies that target neutrophil enzymes and have been detected in the serum of many vasculitis patients.

[23] A biopsy of the affected tissue (such as the skin, the sinuses, lung, artery, nerve, or kidney) is used to make a definitive diagnosis of vasculitis by identifying the pattern of vessel inflammation.

Determining the precise type of vasculitis may be made easier by looking for immunoglobulins and complement on the tissue section as detected by immunofluorescence.