Established on January 8, 1980, it's called Fort Bonifacio College Annex and changed the name into Taguig Municipal High School by memorandum of agreement in July 1979.

The officer-in-charge, Mrs. Isabelita L. Montesa together with the concerned people worked for transferring the school near Arca South (former F.T.I Terminal) complex to accommodate the large number of enrollees.

After the 1986 People Power Revolution, This way for the acquisition of the present location of the school, the former Institution of Rehabilitation for Man (IRM) at New Lower Bicutan.

At Present, Taguig National High School serves more than 2,500 enrollees with 104 faculty members under the leadership of the newly proclaimed principal, Mr. Nelson S. Quintong Students Most of the students enrolled in this school is 50% Roman Catholic, 40% Muslim and the 10% goes to others religions such as Iglesia ni Cristo, Born Again, and Ang Dating Daan.

As of now, the school administration passed a memorandum that French and Portuguese will be offered as voluntarily and optional language (started in 2012).